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The research aim is to identify the key factors influencing patient engagement and, after analysing strategies for patient engagement used worldwide, to assess their suitability for involving patients in the Ga East Municipality, Ghana. Employing a qualitative desk review approach, the study examined existing literature. It analysed global patient engagement frameworks across 20 studies conducted over the last ten years, based on the subcategories of trust, education, leadership and shared understanding. While the review highlighted several implications for health outcomes and patient satisfaction related to patient engagement, it also revealed that various factors, including low National Health Insurance Scheme enrolment, poor communication methods, gender inequities and trust issues, drive patient engagement. The article illustrated that educated, supported and engaged patients in decision-making adhered to treatment recommendations more frequently and expressed greater satisfaction with their care. A review of international frameworks revealed a range of strategies employed globally to enhance patient engagement.